Kittle exited Week 1 with an injury scare; his health and target share are pivotal for SF’s aerial game and Purdy’s eventual return to top-tier fantasy appeal.

Kittle is on Injured Reserve; his absence reduces SF’s short-to-intermediate targets, elevating the need for Purdy to reclaim rhythm and for others to step up in the receiving corps.

Kittle’s IR stint creates a temporary void in SF’s passing game, elevating Aiyuk/Jennings/Pearsall. Return timing remains Week 6 at the earliest, with risk of delay. His eventual reintegration should restore elite TE1 upside, making him a high-reward stash for fantasy teams that can endure the wait.

Kittle’s status on the injury report adds risk to SF’s passing game and red-zone dynamics, potentially dampening his weekly upside until he’s fully cleared.

Kittle’s hamstring injury places Jennings in a larger target window, but his absence also elevates risk if the depth chart cannot compensate. Week 3 could become Jennings’ breakout window if the IR-bound TE remains unavailable.